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Washington University Experience | NEOPLASMS (GLIAL) | Gliosarcoma | 8A Gliosarcoma (Case 8) 1A.jpg
Case 8 History ---- The patient was a 68 year old man with a history of urothelial carcinoma of the bladder, diagnosed five years before his brain surgery, when he presented with a large irregularly enhancing right temporal lobe mass. ---- 8A The neurosurgical specimen is a highly cellular neoplasm with both spindled, sarcoma-like and glioma-like regions. The latter region contains fibrillary and gemistocytic elements, with scattered giant cells as well. In most areas of the sarcoma-like component, there are intersecting fascicles of spindled cells with abundant eosinophilic cytoplasm, resembling fibrosarcoma or leiomyosarcoma. Focally, there is dense hyaline stroma, suggestive of osteoid within an osteosarcoma. In all components, the mitotic index is high and there are foci of both endothelial hyperplasia and pseudopalisading necrosis.
