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Washington University Experience | NEOPLASMS (GLIAL) | Oligodendroglioma - IDH1 mutant, del 1p19q - Grade 3 | 24A2 Oligodendroglioma, anaplastic Grade 3 (Case 24) H&E 60X
The tumor cells have mostly round to oval nuclei with occasional micronucleoli and prominent perinuclear clearing. However, a focal area shows dense cellularity, with increased nuclear atypia, incipient microvascular proliferation, and increased mitotic activity (~8-10/10 HPF). The background neuropil shows microvacuolation, focal radiation necrosis, and regional hyalinized thickening of the vessel walls.
