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Washington University Experience | NEOPLASMS (GLIAL) | Pleomorphic Xanthoastrocytoma (PXA) | 22G3 PXA (Case 22) B1 Ki67 40X
The proliferative activity is increased and involves small as well as large pleomorphic nuclei with an estimated Ki-67/MiB proliferation index of 30%. (Ki67 IHC) --- Tumor cells are negative for IDH1 p.R132H, NeuN, CD34 (highlights vessels), H3K27M mutant protein with retention of H3K27 trimethylation. ---- Fluorescence in situ hybridization studies showed polysomy of chromosome 7 and monosomy of chromosome 10 but are negative for EGFR and NMYC amplification. ---- CARIS molecular genetic analysis showed CDKN2A/B deleted. IDH1/2 mutation not detected. Tert promoter showed a pathogenetic variant and a mutation of BRAF V600E.
