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Washington University Experience | NEOPLASMS (GLIAL) | Subependymal Giant Cell Astrocytoma (SEGA) | 4F Astrocytoma, subependymal giant cell (SEGA Case 4) Ki67 4.jpg
No significant reactivity for proliferation marker Ki67 (MIB-1 antibody) is observed. ---- Ancillary studies (not shown): Reactivity for epithelial membrane antigen (EMA) highlights sparse paranuclear dot-like structures within some apparently non-neoplastic ependymal cells and shows a membrane-staining pattern in rare epithelioid cells. ---- Comment: Although physical exam reportedly identified no stigmata consistent with tuberous sclerosis (TSC) in this patient, a low threshold might be maintained for investigating other TSC-associated health issues, given the variable penetrance and variable severity of that disorder.
