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Washington University Experience | NEOPLASMS (METASTASES) | Microscopic | 99A Metastasis, lung, squamous (Case 99) H&E 40X
Case 99 History ---- The patient is a 63yo female with a history of squamous cell carcinoma of lung status post chemotherapy and resection, who presented with one week of short term memory and concentration difficulties. MRI showed a 4.6 cm peripherally enhancing left frontal lesion and a 1.1 cm peripherally enhancing right frontal lesion concerning for metastatic disease. Multifocal primary high grade glial neoplasm was considered less likely. Operative procedure: Craniotomy excision intracranial mass ---- 99A H&E-stained sections show a metastatic non-keratinizing squamous cell carcinoma. Marked pleomorphism, brisk mitoses and tumor necrosis are noted. Adjacent brain parenchyma demonstrates marked reactive astrocytosis. (H&E)
