Table of Contents
Washington University Experience | NEOPLASMS (NEURONAL) | DNET | 21A1 DNET (Case 21) Whole Mount
Case 21 History ---- The patient is a 21 year old man who initially presented at the age of 14 with an acute intracerebral hemorrhage and was found to have a neoplasm (unclear histology). He subsequently had seizures and gradual increase in the tumor size and recently underwent resection. ---- 21A1-6 Sections reveal multiple fragments of neocortex and mesial temporal structures involved by a low grade glial tumor with variable morphologic features. In many areas, there are variably sized mucin-rich nodules, located either within neocortex or within the hippocampus. The majority of tumor cells in these regions resemble oligodendroglioma containing small round uniform nuclei with delicate chromatin and clear perinuclear halos. These mucin-rich nodules have a patterned appearance, with the oligodendroglioma-like cells mostly lining up around blood vessels and small aggregates of axons. Floating neurons are also seen within pools of basophilic mucin. Within the hippocampus, some of the granular neurons of the dentate gyrus are also involved.
