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Washington University Experience | NEOPLASMS (NEURONAL) | DNET | 23A1 DNET (Case 23) H&E whole mount

Case 23 History ---- The patient is a 30 year old man with a subcortical lesion in the posterior cingulate gyrus. Operative procedure: Biopsy ---- 23A1-5 Sections reveal multiple fragments of neocortex and superficial white matter. The tissue is involved by a moderately cellular lesion that includes relatively well demarcated mucin-rich patterned nodules, with numerous small tumor cells containing round regular nuclei, delicate chromatin and clear perinuclear halos. Many of these cells are arranged around capillaries or axonal bundles, creating a patterned appearance. Additionally, there are intratumoral neurons that do not appear dysmorphic, but appear to be floating within pools of basophilic mucin ("floating neurons"). Scattered oligodendroglioma-like cells infiltrate superficially into adjacent brain parenchyma.

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