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Washington University Experience | NEOPLASMS (NEURONAL) | Ganglioglioma | 20A1 Ganglioglioma (Case 20) H&E whole mount copy
Case 20 History ---- The patient is a 16 year old girl with history of intractable complex partial epilepsy and generalized tonic clonic seizures. She has a history of infantile spasms starting at 13 months of age. She was on medication for 2 years, and then seizure free until she was about 6 years old when she took Ritalin x1 and entered status epilepticus for about 4-5 hours. She had a generalized tonic clonic seizure also in 2005, and then in 2010 had seizures in July and September. She is now experiencing complex partial seizures 4-5 days per week, at least 1 per day. PET shows bilateral temporal hypometabolism, more prominent on the left, suggesting left lateralization of the epileptogenic focus. MRI imaging shows a T2-hyperintense expansile lesion within the left parahippocampal gyrus and hippocampus. Radiological differential diagnosis: Cortical dysplasia, ganglioglioma, pleomorphic xanthoastrocytoma, or other glial neoplasm. Operative procedure: Left sided craniotomy with resection of temporal lobe lesion. ---- 20A1 This whole mount of the neurosurgical specimen shows two aspects of the neoplasm (arrows).(H&E)
