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Washington University Experience | NEOPLASMS (NEURONAL) | Lhermitte-Duclos Disease | 2B1 Lhermitte-Duclos (Case 2) C5 next to Area A H&E 4X copy (2) copy
2B1-4 This folium shows the delicate central white matter tract (arrow, 2B1) of the arbor vitae surrounded on both sides by a thickened granule cell layer (between arrowheads, 2B1) which have lost the majority of normal granule cells with replacement by enlarged, cytoplasm rich ganglion-like cells. The gangliocytic proliferation is composed of cells with rather abundant eosinophilic cytoplasm, round to ovoid nuclei with crisp nuclear membranes, prominent nucleoli, and coarsely granular or speckled chromatin; some authors have described these as "hypertrophic granule cells," and this attribute is appreciated in areas of transition
