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Washington University Experience | NEOPLASMS (NEURONAL) | Lhermitte-Duclos Disease | 2B2 Lhermitte-Duclos (Case 2) C5 next to Area A H&E 4X copy
Higher magnification image of image #2B1.The majority of normal granule cells have been replaced by enlarged, cytoplasm rich ganglion-like cells. The gangliocytic proliferation is composed of cells with rather abundant eosinophilic cytoplasm, round to ovoid nuclei with crisp nuclear membranes, prominent nucleoli, and coarsely granular or speckled chromatin; some authors have described these as "hypertrophic granule cells," and this attribute is appreciated in areas of transition
