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Washington University Experience | NEOPLASMS (NEURONAL) | Papillary Glioneuronal Tumor (PGNT) | 1I Papillary Glioneuronal Tumor (PGNT) (Case 1) Ki67 1
Ki67 proliferation rate is ~2% (Ki67 IHC). ---- Comment: The relative contribution of glial and neuronal elements varies from place to place in the tumor with some areas rich in side-by-side papillary cores appearing mostly glial in immunostains and in other areas greater space between papillae occupied by neural immunoreactive elements. The collective morphological and immunohistochemical features are consistent with papillary glioneuronal tumor, WHO grade I. Genomic investigation (CARIS) showed FGFR1-TACC1 fusion. Low‑grade glioneuronal tumors with FGFR2 fusion is not pathognomonic of PGNT but may be found in PLNTY and extra-ventricular neurocytoma.
