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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 15B2 PA, CR in nl (Case 14)

Although there is significant CAM5.2 staining in this image, tumor cells largely lack the concentric pattern of Crooke’s change. ---- Not shown: Immunohistochemical studies show tumor cells to be diffusely modestly positive for ACTH and show patchy weak positivity with LH. Scattered rare tumor cells are positive with prolactin and GH. Few mitoses are seen in tumor cells but in some areas Ki67 is relatively elevated reaching ~3.4%. ---- Comment: The overall morphological and immunohistochemical findings are consistent with a corticotrophic pituitary adenoma.

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