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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 16D3 PA, CR (Case 16) CAM5.2 40X
Immunohistochemistry for CAM 5.2 shows that essentially all within the microadenoma have Crooke's hyaline change, and the non-tumorous gland has a lesser degree of Crooke’s change. ---- Not shown: There are scattered inflammatory cells that show positivity for the proliferation marker Ki67, but the glandular tissue, including the nodular focus, is negative. ---- Comment: The overall findings are those of anterior pituitary gland with Crooke's hyaline change and a microscopic focus consistent with a microadenoma, ACTH cell type with Crooke’s cell change ("Crooke cell adenoma").
