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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 5B2 PA, ACTH, CR (Case 5) CAM52 1.jpg
Higher magnification of Crooke's change. (CAM5.2 IHC) ---- Crooke's hyaline change is seen in a minority of tumor cells and in non-neoplastic gland. (H&E) ---- Not shown: Ki67 proliferative index reaches up to 2%. ACTH immunostain highlights cytoplasmic staining in the majority of the tumor cells.
