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Washington University Experience | NEOPLASMS - CRANIAL AND PARASPINAL NERVEs | Malignant Peripheral Nerve Sheath Tumor (MPNST) | 17A3 MPNST, low grade (Case 17) H&E 3.jpg
Focally, the tumor is hypercellular and arranged in a herringbone or storiform pattern of intersecting fascicles. The tumor cells in these areas are enlarged, pleomorphic, including bizarre forms, and contain overlapping, hyperchromatic nuclei. However, mitoses are difficult to find and necrosis is not seen. There is a patchy chronic inflammatory infiltrate (lymphocytes, plasma-cells and mast cells) in the background as well. This portion of the tumor is consistent with malignant peripheral nerve sheath tumor (MPNST).
