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Washington University Experience | NEOPLASMS - CRANIAL AND PARASPINAL NERVEs | Neurofibroma | 14A2 Neurofibroma, plexiform (Case 14) H&E whole mount 1

The provided sections show a neoplasm that involves and expands multiple associated fascicles of peripheral nerve. The neoplasm, well circumscribed by perineurium, is composed of elongated small spindled cells with hyperchromatic, thin, tapered nuclei and interspersed bundles of collagen, embedded within a mucinous matrix. Cell density ranges from low to moderate. There is no evidence of significant mitotic density, or necrosis. (H&E)

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