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Washington University Experience | NEOPLASMS (HEMATOLYMPHOID) | Langerhans Cell Histiocytosis (LCH) | 12E LCH (Case 12) S100 3
12E Similarly, S100 stains Langerhans cells but failed to stain multinucleated giant cells or non-neoplastic reactive elements (S100 IHC) ---- The admixed giant cells are positive for CD68 and CD163, but negative for CD1a and S-100; this immunophenotype is most compatible with osteoclast or reactive giant cell origin.
