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Washington University Experience | NEOPLASMS (HEMATOLYMPHOID) | Lymphoma, immune-compromised | 6F Lymphoma (Case 6) GFAP 1

There is a significant proliferation of reactive astrocytes (GFAP IHC) ---- The interpretation was that the patient had post transplant lymphoproliferative disease (PTLD) with multiple brain lesions and associated edema. The morphological, immunohistochemical and in-situ hybridization studies support a diagnosis of primary CNS non-Hodgkin's lymphoma, B-cell immunophenotype. The presence of EBER positivity and extensive necrosis is consistent with a primary CNS lymphoma arising within an immunosuppressed patient.

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