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Washington University Experience | NEOPLASMS (HEMATOLYMPHOID) | Lymphoma, secondary | 12B2 Lymphoma, secondary (Case 12) H&E 1

12B2-5 The leptomeninges covering the cerebellar folia show extensive accumulation of an atypical lymphoid infiltrate composed predominantly of large lymphoid cells with a moderate amount of cytoplasm and oval to enlarged irregular-shaped nuclei, sometimes with prominent nucleoli, intermixed with small mature round lymphocytes. This process is seen to extend down Virchow-Robin spaces and focally infiltrate into the underlying cerebellar parenchyma, in some areas being associated with tissue destruction with accumulation of foamy histiocytes, reactive astrocytes, and axonal spheroids.

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