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Washington University Experience | NEOPLASMS (HEMATOLYMPHOID) | Plasmacytoma | 11B1 Plasma Cell Neoplasm (Case 11) H&E 20X 1
11B1-3 Microscopic examination of the epidural spinal tumor shows neoplastic cells with plasmacytoid features and a sheetlike growth pattern. The neoplastic cells are angulated, epithelioid, and have irregularly shaped round nuclei with granular to clumped chromatin that also contain small cherry-red nucleoli. The cells have moderate amounts of eccentrically located amphiphilic cytoplasm and show eosinophilic to cleared perinuclear hofs (Golgi zone clearing). Occasional cells take on a flame shape or comet-like morphology. Mitoses are present and there is abundant karyorrhectic debris.
