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Washington University Experience | NEOPLASMS (HEMATOLYMPHOID) | Rosai-Dorfman Disease | 7A1 (Case 7) 10X copy
Case 7 History ---- This patient was a 70 year old male who presented with visual loss which progressed over the next 2 years. MRI revealed a diffuse intracranial pachymeningeal enhancement. Subsequent pathologic characterization of the biopsy in the anterior fossa/parasellar region was difficult (7A1-3). ---- 7A1-3 The scattered meningothelial cell clusters (arrowhead, 7A1, seen at higher magnification in 7A2) admixed with an mixed inflammatory cell infiltrate resulted in various diagnoses of "diffuse meningothelial proliferation/meningeal meningiomatosis, with chronic pachymeningitis", "diffuse meningothelial hyperplasia", and "meningothelial cells and chronic inflammation" when sent in consultation. FISH analysis of the 2005 specimen reveal polysomies of chromosomes 18 and 22, but normal dosages of chromosomes 1 and 14. Post-surgical treatment included steroids, but the patient's condition did not improve.
