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Washington University Experience | NEOPLASMS (MENINGIOMA) | Anaplastic | 10B1 Meningioma, anaplastic (Case 10) H&E 2

10B1-4 There are areas with spindled to epithelioid architecture with focal calcifications and occasional whorl formation. Hyalinized vessels are present and numerous. A large portion of this neoplasm is sheeted with increased cellularity. Large areas of necrosis with focal pseudopalisading necrosis, microvascular proliferation and frank anaplasia are also seen with carcinoma-like and sarcoma-like cytologic features. Perivascular lymphocytic cuffing is also seen. Mitotic figures are prevalent and the mitotic index reaches 5 mitotic figures per 10 HPF in multiple areas.

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