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Washington University Experience | NEOPLASMS (MENINGIOMA) | Anaplastic | 25C3 Meningioma, anaplastic (Case 25) p16red-cent 9 grn Homozygous p16 deletio - Copy
In this particular case, the tumor cells show evidence of deletions involving 22q, 1p, and 14q. Additionally, there are chromosome 9 deletions, including homozygous deletions of the p16 region. ---- Comment: The morphologic, immunohistochemical and genetic features are consistent with the diagnosis of anaplastic meningioma, WHO grade III. Additionally, the loss of the p16 region has been associated with a more aggressive subset of anaplastic meningiomas. Lastly, the association of this neoplasm with a pre-existing arachnoid cyst is intriguing. This has never been reported previously. It suggests possible malignant transformation of the meningothelial lining of the cyst.
