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Washington University Experience | NEOPLASMS (MENINGIOMA) | Anaplastic | 4B2 Meningioma, Anaplastic (Case 4) B3 H&E 20X
4B2,3 Histological sections of the right parietal tumor showed cells with inconspicuous or prominent nucleoli, increased nuclear-to-cytoplasmic ratio ('small cell' formation), spontaneous macronecrosis with angiocentric sparing and micronecrosis with tumor cell pseudopalisading, and brain invasion, evident focally. Mitotic figures are abundant, ranging up to 24/10HPF. This histological pattern is consistent with anaplastic meningioma, WHO grade III.
