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Washington University Experience | NEOPLASMS (MENINGIOMA) | Brain Invasion | 7A2 Meningioma, atypical w brain invasion (Case 7) H&E 2
The tumor is a hypercellular meningioma composed predominantly of fascicles and whorls of spindled-cells with eosinophilic cytoplasm, ovoid nuclei, and occasional intranuclear cytoplasmic pseudo-inclusions. In many areas, the neoplastic cells show small cell change, spontaneous necrosis, macronucleoli and mitoses (<4/10HPF). Unmistakable brain invasion is identified as well as involvement of bone. These histological findings support the diagnosis of atypical meningioma with brain invasion, WHO grade 2.
