Table of Contents

Washington University Experience | NEOPLASMS (MENINGIOMA) | Chordoid | 5B Meningioma, Chordoid (Case 5) PR

Immunohistochemically stained sections show nuclear reactivity for progesterone receptor in essentially all tumor cells. ---- Ancillary Data (not shown): Nuclear reactivity for proliferation marker Ki67 is present at low density, estimated at less than 1% of tumor cells generally, and focally ranging up to 1.9 % of tumor cells, counted focally. This histological/immunohistochemical pattern is that of a chordoid meningioma, WHO grade 2. The write up at the time stated “Although this tumor does not fulfill other independent criteria for a diagnosis of 'atypical,' or grade II (including either: brain invasion; increased proliferative index; or a constellation of hypercellularity, 'sheeting,' macronucleoli, 'small cell change,' and necrosis), cases in which a chordoid histological pattern predominates have an increased tendency to recur, on par with atypical meningiomas.”

---