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Washington University Experience | NEOPLASMS (MENINGIOMA) | Meningioma - Clear cell | 17A1 Clear cell meningioma (Case 17) H&E 20X
Case 17 History ---- The patient was an 80 year old man with a 4.0 cm right parieto-occipital meningioma. The tumor had eroded dura, and was associated with hemispheric edema. ---- 17A1,2 Sections reveal a meningothelial meningioma with a number of aggressive histologic features. The latter include sheeting (patternless) architecture, focal small cell (high N/C ratio) change, a focally elevated mitotic index of up to 4-5/10HPF and clear cell features. The latter finding is not diffuse and is associated with a perivascular "blocky" collagen deposition only in some regions. Other regions of this neoplasm demonstrate increased vascularity and moderate to marked nuclear pleomorphism.
