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Washington University Experience | NEOPLASMS (MENINGIOMA) | Rhabdoid | 2E Meningioma, pap&rhab (Case 2) Ki67 1.jpg
The Ki-67 proliferative index is moderate (Ki67 IHC) ---- .Ancillary studies (not shown): GFAP and S-100 both highlight gliotic but non-invaded brain. ---- FISH was performed to assess the status of chromosomal arms 22q, 18p, 14q and 1p. Deletions of these arms are common in meningiomas, especially higher grade examples. In particular, 1p and 14q have been associated with atypical and anaplastic meningiomas as well as a higher risk of recurrence and shorter progression free survival. In this particular case, polysomies (i.e., gains) of chromosomes 1, 14, 18 and 22 are detected. This FISH pattern is considered non-specific. ---- Comment: The extended survival (~11 years) is unusual for an initially graded WHO grade III rhabdoid/papillary meningioma. Re-grading of this tumor using WHO 2021 criteria would designate it as a meningioma with focal rhabdoid and papillary features, WHO Grade 2.
