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Washington University Experience | NEURODEGENERATION | ALS | 3G1 ALS (Case 3) N8 XII nucTDP43 60X 2
3G1,2 The hypoglossal nucleus of the medulla demonstrates mild neuron loss and astrocytosis by H&E stain (not shown) which is confirmed by TDP43 immunoreactivity. The medullary pyramidal tracts show axon loss, microvacuolation, and gliosis. Injury to the descending pyramidal tracts within the medulla; the latter findings are also confirmed with Bielschowsky silver and LFB-PAS staining.
