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Washington University Experience | NEURODEGENERATION | Aging-Related Astroglial Tauopathy (ARTAG) | 2A0 Case 2 History
Case 2 History ---- This male patient began to have progressively worsening memory at the age of 81. At his first assessment in 2006 he was diagnosed with mild cognitive impairment. Over the next few years he gradually progressed in his cognitive impairment, which was predominantly related to memory loss. He was converted to a diagnosis of Alzheimer disease and mild depression in April 2012 at age 88 years. Over the next three years his cognitive impairment continued to progress and he was assigned a CDR stage 3 (severe dementia) at the end of life. He developed parkinsonism (resting tremor) but did not meet criteria for dementia with Lewy bodies. In summary, he died after a ten-year history of slowly progressive cognitive impairment and more rapid progression in the last two years of life; during the course of the illness parkinsonian features were noted. He entered hospice and died of inanition in July 2015. ---- At autopsy the fresh, unfixed brain weighed 1410g and was grossly normal. The main neuropathologic findings after histologic and immunohistological study of this case were diffuse Lewy body disease (DLBD, dementia with Lewy bodies), primary age-related tauopathy (PART), and Argyrophilic grain disease (AGD). Minor changes included Alzheimer disease neuropathologic change (ADNC, A1B2C0) which is consistent with nearly absent AD, mild TDP-43 proteinopathy and mild small vessel disease.
