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Washington University Experience | NEURODEGENERATION | Alzheimer Disease | Gross Pathology | 3A5 AD (Case 3) 10
The occipital lobe is comparably less involved. ---- Neuro Diagnosis Comment: The principal neuropathological finding of this case is Alzheimer disease (AD). Beta-amyloid plaques, neuritic plaques, and neurofibrillary tangles (NFT) are present in distributions and densities consistent with a neuropathological diagnosis of Alzheimer disease (AD) by Khachaturian, CERAD, NIA-Reagan Institute criteria that the patient's dementia can be attributed to AD pathology. In the more recent NIA-AA staging system, this case has neuropathological change consistent with AD (A3B3C3). Although ballooned neurons are present in the amygdala, other diagnostic features of argyrophilic grain disease are absent. In addition to the diagnostic features of AD, vascular pathologies are additional findings in this case, including mild cerebral amyloid angiopathy, mild-to-moderate arteriolosclerosis, and severe (but non-occlusive) atherosclerosis.
