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Washington University Experience | NEURODEGENERATION | Alzheimer Disease | Synaptic Pathology | 1B1 AD (Case 1) PHF 1
The distribution of pTau had a clear predilection for the hippocampal formation and medial temporal lobe. Although there are numerous neurofibrillary tangles in the hippocampus and adjacent temporal lobe as demonstrated with H&E, Bielschowsky and antisera directed against paired helical filaments (PHF-1) the majority of the neocortex was almost entirely spared. (PHF IHC)
