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Washington University Experience | NEURODEGENERATION | Argyrophilic Grain Disease (AGD) | 1A0 Case 1 History
Case 1 History ---- This 79year old male patient initially began having memory changes in 2004 and was diagnosed with Mild Cognitive Impairment of the Alzheimer's type in June 2005 (Global CDR = 0.5). His memory changes had been gradually progressive but his most recent Global CDR score in 6/2011 was 0.5. In the last months of his life, he experienced severe memory loss. He had difficulty communicating, could not recognize familiar people and was disoriented to place and time. He did not participate in activities at the memory care center. He was able to feed himself but lost his appetite shortly before he died. He needed full assistance with dressing and bathing. He was doubly incontinent. He displayed atypical features during the latter course of his assumed Alzheimer's disease. He started to become unsteady and had multiple falls in the spring of 2010. He was able to use a walker from the spring of 2010 until February 2012. In February 2012, he became wheelchair bound. He was aphasic especially in the last several months of his life. He died of inanition in September 2012. At the time of death, his global CDR was 3.0, indicating severe Alzheimer's disease. ---- At autopsy the fresh, unfixed brain weighed 1390g. Due to the rapid progression of the severity of his dementia (change in CDR greater than 2 in the terminal year of life) samples of frozen and fixed brain tissue were forwarded to the National Prion Disease Pathology Surveillance Center which reported no evidence for prion disease.
