Table of Contents
Washington University Experience | NEURODEGENERATION | Corticobasal Degeneration (CBD) | 3A0 Case 3 History
Case 3 History ---- The subject was a 59 year old left-handed male with an approximately 2-4 year history of increased forgetfulness and deterioration in his job performance. The onset of symptoms was approximately at the age of 55. At age 61, he was reported to have gradually increasing difficulties and the family had become increasingly involved with his affairs since he retired. The primary clinician assessed this to be mild DAT with a CDR of 1. In August 1990, the patient moved to a nursing home secondary to problems living alone. He had increasing difficulties with getting lost, inability to put gloves on correctly, inability to obey simple commands. It was noted that he would repeat the same question and would lose his track of thought during conversations. His judgment had deteriorated substantially as did his ability to perform household chores. He had difficulties in taking off his shoes and socks in a proper sequence. He did remember his educational history and his work history. Besides a motor apraxia, there were no other motor problems. He did not remember his recent personal events. The impression from this interview was that he had atypical DAT with possible posterior cortical atrophy. He was rated CDR 2. The T3 assessment occurred in 7/92 (63yo). He would forget within minutes of memory testing and was poorly oriented. His gait was described as slow. The impression of the clinician was DAT. The nurse clinician's CDR pre-terminally was a 3. At this assessment in 1992, there were no symptoms of extrapyramidal disorder other than his gait was described as slow; specifically no masking, bradykinesia or cogwheeling rigidity were noted. He died in 1/1996 at the age of 66 from pneumonia approximately ten years after the onset of the first symptoms finally reaching CDR 3. His diagnosis based on the above history was DAT with unusual features (early onset and posterior cortical dysfunction).
