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Washington University Experience | NEURODEGENERATION | Corticobasal Degeneration (CBD) | 8A0 Case 8 History
Case 8 History ---- This patient had an eight or nine year history of progressive dementia with an initial presentation characteristic for dementia of the Alzheimer type (e.g., ”memory loss“) with frequent repetition and getting lost when driving; progressing to impairment with the household finances, operation of appliances, and bridge ability). At about five or six years following onset of dementia, he developed disproportionate language dysfunction. Throughout this course, he had inappropriate comments of a sexual nature but no other disruptive behavioral disturbances. Finally, about seven years after onset, he developed a ”useless“ right upper extremity with right-sided motor findings, both extrapyramidal (e.g., rigidity; parkinsonian gait) and corticospinal (extensor plantar sign). A year prior to death, on head MRI, there was no report of focal cerebral degeneration. Corticobasal degeneration is associated with frontal lobe features, aphasia of the nonfluent type, and asymmetric motor findings. He satisfies all these criteria, but two (aphasia; asymmetry), appeared only late in the course of his progressive dementia. At time of death he was rated a CDR 3.
