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Washington University Experience | NEURODEGENERATION | Hippocampal Sclerosis of Aging | 7G Case 7 Denouement
Neuro Final Diagnosis ---- Hippocampal sclerosis ---- Neuro Diagnosis Comment: This is an unusual and interesting case. Despite the clinical history of gradually progressing dementia and the patient's age (93 year old) there is a virtual absence of plaques and tangles. There is no evidence of dementia with Lewy bodies, frontotemporal degeneration, argyrophilic grain disease or any other neurodegenerative disorder. Sections of the neocortex show a variable degree of neuron loss or reactive gliosis, and no beta amyloid plaques, neurofibrillary tangles and neuritic plaques. The only significant neuropathological finding, and the presumed cause of her clinical symptoms, is hippocampal sclerosis of aging.
