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Washington University Experience | NEURODEGENERATION | Huntington Disease | 15B1 Huntington's Dz (Case 15) L1 10X
15B1,2 The frontal lobes showed mild neuronal loss and gliosis throughout the neocortex. No beta-amyloid plaques and no argyrophilic neuritic plaques or neurofibrillary tangles were present. No tau or alpha-synuclein pathology was present. Polyglutamine (1C2) immunohistochemistry (not shown) revealed numerous neuronal intranuclear inclusions and sparse dystrophic neurites. 1C2-immunoreactivity was also seen in granules within the cytoplasm of some neurons.
