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Washington University Experience | NEURODEGENERATION | Huntington Disease | 18A0 Case 18 History
Case 18 History
The patient was a 56yo female with a 13 year history of symptomatic Huntington disease (HD) that started with cognitive impairment at age 43. This substantially increased over the next three years and then she developed chorea and personality changes. By age 47, she had balance and walking problems. By age 51, she had only mild chorea, some swallowing trouble, cognitive impairment, depression, anxiety, and urinary urgency. In the last several years, irritability increased, falling increased, anxiety worsened and dementia progressed. Her chorea remained relatively mild. HD testing confirmed the disease with 44 CAG repeats. She had a father with presumed HD. She was on hospice for the last 3 years. Her oral intake decreased and she died of inanition and dehydration due to HD in 2014. She had: MMSE in 2009 was 23/30; UHDRS motor scale: 50 (7/2011); UHDRS functional assessment: 17 (9/2009) and UHDRS independence scale: 65 (9/2009). Medications included citalopram, levothyroxine, Lotensin, prempro, quetiapine, fexofenadine and Flonase
