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Washington University Experience | NEURODEGENERATION | Huntington Disease | 2D3 Huntington's Dz (Case 2) N1 1C2 40X
Immunostain shows scattered basal ganglia neurons with positive intranuclear and intracytoplasmic inclusions. (1C2 IHC) ---- Not shown: Immunohistochemical staining using the 10D5 antibody for beta amyloid plaques is essentially negative in the frontal lobe. The paired-helical filament (PHF) immunostain shows an isolated positive neurofibrillary tangle in the frontal cortex. ---- Neuro Final Diagnosis: Huntington Disease