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Washington University Experience | NEURODEGENERATION | Huntington Disease | 3D3 Huntington's Dz (Case 3) 1C2 (Anti-polyglutamine) 2

In the caudate nucleus and putamen, there are polyglutamine-positive (1C2) inclusions, within the cytoplasm and nucleus. ---- Not shown: There is subtle neuronal loss and gliosis throughout the neocortex. No neurofibrillary tangles are present in either the hippocampus or parahippocampal gyrus. There are no beta-amyloid plaques. No Pick or Lewy bodies are present. ---- Neuro Diagnosis Comment: Macroscopy shows atrophy of the caudate nucleus consistent with Grade 2 (range 0-4 increasing with severity) in the Huntington's Disease Neuropathological Grading Scheme of Vonsattel et al. (PMID: 9596408). There was no evidence of any other neurodegenerative disease.

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