Table of Contents
Washington University Experience | NEURODEGENERATION | Lewy Body Disease (LBD) | 2 LBD - Gross Pathology - Cerebrum LBD -Dementia | 11B Case 11 Denouement
Final Neuropathologic Diagnoses: Parkinson disease dementia (diffuse Lewy body disease/dementia with Lewy bodies); Alzheimer's disease; Hippocampal sclerosis in left temporal lobe; Small vessel disease ---- Frequent beta-amyloid plaques, but no neuritic plaques, and only few neurofibrillary tangles, largely in the medial temporal lobe, are present consistent with Braak and Braak neurofibrillary tangle stage III (range: 0, I-VI) and amyloid stage B (range: 0, A-C). These findings indicate the presence of Alzheimer's disease (AD) by Khachaturian criteria, but the absence of neurotic plaques excludes AD by the CERAD and NIA-Reagan Institute criteria for the neuropathological diagnosis of AD. In addition to modest tau and beta-amyloid pathology, this case also displays alpha-synuclein-positive inclusions in the form of Lewy bodies and Lewy neurites in brain stem, limbic, and neocortical areas.
