Table of Contents

Washington University Experience | NEURODEGENERATION | Lewy Body Disease (LBD) | 2 LBD - Gross Pathology - Cerebrum LBD -Dementia | 3A3 Limbic DLBD & Hippocampal sclerosis (Case 3) _7

The hippocampus was substantially atrophic. ---- Final Neuropathologic Diagnoses: Diffuse Lewy body disease (limbic stage) ---- Hippocampal sclerosis ---- Primary age-related tauopathy (PART) ---- Alzheimer disease neuropathologic change (ADNC, Low: A1, B2, C0) ---- Not shown: This case displays alpha-synuclein-positive inclusions in the form of Lewy bodies and Lewy neurites in brainstem, limbic and neocortical areas. This brain is remarkable in that AD pathology is almost entirely absent. A few solitary diffuse beta-amyloid plaques were only found in the frontal and parietal lobes and amygdala. There are no neuritic plaques and neurofibrillary tangles are confined largely to the medial temporal lobe

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