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Washington University Experience | NEURODEGENERATION | Lewy Body Disease (LBD) | 3 LBD - Gross Pathology - Pallidotomy and DBS | 1B Case 1 Denouement
Neuro Final Diagnosis: Idiopathic Lewy Body Parkinson's disease; Pallidotomy and subthalamic stimulator scars, frontal lobe, basal ganglia and thalamus; Infarct, subacute, cervical-thoracic spinal cord. ---- Not shown: Microscopic examination showed the number of senile plaques and neurofibrillary tangles does not meet the CERAD or Khachaturian criteria for the diagnosis of Alzheimer’s disease. Sections of the midbrain and pons show loss of pigmented neurons of the substantia nigra and locus ceruleus with evidence of numerous Lewy bodies, astrocytosis and extraneural pigment, both free in the neuropil and in macrophages. Sections of the cervical/thoracic spinal cord were remarkable for a single focus of necrosis, likely ischemic, involving a portion of the lateral funiculus of white matter extending into the anterior horn and into the medial portion of the opposite side in the vicinity of the central canal. The cord lesion lacked any evidence of hemorrhage.
