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Washington University Experience | NEURODEGENERATION | Neuronal Nuclear Inclusion Disease (NIID) | 1A2 Neuron, NIID (S08-38642) H&E 8 copy

1A2 Cortical neurons include a population undergoing dark cell change (created as a touch artifact, particularly common in neurosurgical specimens). Within the nuclei of the pyramidal neuron shown is a pale eosinophilic inclusion (arrow) which is immediately adjacent to a dark nucleolus. A second neuron not showing dark cell change exhibits an eosinophilic inclusion (arrowhead) but no nucleolus. Inclusions are several microns in diameter in this field. (H&E)

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