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Washington University Experience | NEURODEGENERATION | Neuronal Nuclear Inclusion Disease (NIID) | 3A1 NIID (AANP DSS 2005-3) cortex cerebral 20X 1
At autopsy the fresh brain weighed 1425g. Significant findings were generalized muscle atrophy and emaciation, bilateral pulmonary lobar consolidation and pericardial effusion. Examination of the fixed hemisected brain was unremarkable except for mild atrophy of the cerebellar hemisphere and vermis. The substantia nigra was not grossly pigmented. Mild atrophy of the ventral roots of the spinal cord was evident. Multiple cross sections of the spinal cord showed no other gross abnormalities. ---- 3A1 At low magnification there is a mild depopulation of neurons and minimal astrocytosis. (H&E)
