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Washington University Experience | NEURODEGENERATION | Neuronal Intermediate Filament Inclusion Disease (NIFID) | 1A0 Case 1 History
Case 1 History (Case #2 in Molina-Porcel L, et al., PMID: 18268200, thanks Nigel Cairns) ---- A 70-year-old woman with diabetes mellitus and hypertension developed progressive tremor, mild speech disturbances and experienced multiple falls. The initial neurological examination showed mild dysarthria, hypomimia, mild rigid-kinetic left-predominant parkinsonism, and bilateral rest and postural tremor. The results of oculomotor testing were normal. No dysautonomia was present. Her grandmother reportedly had had similar symptoms, but medical records were not available. Cranial computed tomography disclosed mild cortical-subcortical atrophy. The clinical impression was atypical parkinsonism. Levodopa therapy was started, but no response as obtained with 450 mg/d. The disease progressed rapidly, and the patient developed significant gait disturbances, experienced falls, and developed frontal-subcortical cognitive impairment. She was institutionalized 2 years after disease onset. She died at the age of 75 years, and a neuropathological study was performed.
