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Washington University Experience | NEURODEGENERATION | Neuronal Intermediate Filament Inclusion Disease (NIFID) | 1A1 NIFID (Case 1) STG H&E 14 copy

Gross Pathology (not shown): The brain weighed 1040 g and showed moderate global atrophy predominantly involving the parietal lobes. ---- The microscopic study revealed pale neuronal intracytoplasmic inclusions, demonstrated by hematoxylin-eosin staining in the neocortex, striatal nuclei, thalami, and several nuclei of the brainstem, including the pons. ---- 1A1-5 H&E stained superior temporal gyrus (STG) shows a baseline of modest neuron loss and astrocytosis. ---- 1A1,2 Cytoplasmic inclusions in neurons (arrows) may be difficult to see at low magnification. (H&E)

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