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Washington University Experience | NEURODEGENERATION | Pick Disease | 4B Case 4 Denouement
Microscopic pathology (Slides are no longer available) I have included this case even without surviving glass slides and microscopic pathology because the CNS showed a characteristic set of unarguable pathologic changes which establish the diagnosis of Pick disease. The frontal and temporal cortex, the hippocampus and parahippocampal gyri showed marked neuron loss and gliosis. A number of inclusions were seen in the cortical neurons. Classic Pick bodies were numerous and present in the areas of neuronal loss. They were especially numerous in the hippocampus where they were found in pyramidal cells of Ammon’s horn and the granular cells of the dentate gyrus. They were also numerous in the anterior parietal cortex where neuronal loss and gliosis was only mild. They were easily found in the frontal and temporal lobes. Bielschowsky silver stain identified scattered Pick bodies.
