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Washington University Experience | NEURODEGENERATION | Pick Disease | 5E Case 5 Denouement
Neuropathologic Diagnosis Comment: In summary, this patients dementia and associated neurological impairments and behavioral changes can be attributed to Pick disease. Notably absent are: neuritic plaques and neurofibrillary tangles {to support a clinicopathologic diagnosis of Alzheimer disease}; 'tufted' astrocytes (to support a diagnosis of progressive supranuclear palsy); 'astrocytic plaques' (to support a diagnosis of corticobasal degeneration); inclusions immunoreactive for phosphorylated TDP-43 (to support a different form of FTLD); and inclusions immunoreactive for alpha-synuclein (to support a diagnosis of Lewy body disease). Arteriolosclerosis, rare amyloid plaques, and rare foci of ARTAG, though present, are not likely to have contributed significantly to signs, symptoms, or greater neurological decline. No other neurodegenerative diseases are identified.
