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Washington University Experience | NEURODEGENERATION | Primary Age-Related Tauopathy (PART) | 1A0 Case 1 History
Case 1 History ---- This 91 year old male began to have progressively worsening memory at the age of 81 years. At his assessment 9 years before his death, he was diagnosed with mild cognitive impairment. Over the next few years he gradually progressed in his cognitive impairment, which was predominantly related to memory loss. He was converted to a diagnosis of Alzheimer disease and mild depression in April 2012 at age 88 years. Over the next three years his cognitive impairment continued to progress and he was given a CDR stage 3 (severe dementia) at the end of life. He developed parkinsonism (resting tremor) but did not meet criteria for dementia with Lewy bodies. In summary, this patient died after a ten-year history of slowly progressive cognitive impairment and more rapid progression in the last two years of life; during the course of the illness parkinsonian features were noted. He entered hospice and died of inanition in July 2015. ---- The fresh, unfixed-brain weighed 1410g.
